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To prime Ventolin HFA, release 4 sprays into the air away from the face, shaking well before each spray. Therefore, Ventolin HFA, like all other sympathomimetic amines, should be used with caution in patients with underlying cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. Over the 4-week treatment period, there were no treatment differences in asthma symptom scores between the groups receiving Ventolin HFA 90 mcg, Ventolin HFA 180 mcg, and placebo in either study. The data from pediatric patients are based upon 1 clinical trial in which 46 patients with asthma 4 to 11 years of age were treated with Ventolin HFA 2 inhalations 4 times daily for 2 weeks’ duration. Table 1 lists the incidence of all adverse reactions (whether considered by the investigator to be related or unrelated to drug) from these studies that occurred at a rate of 3% or greater in the group treated with Ventolin HFA and more frequently in the group treated with Ventolin HFA than in the HFA-134a placebo inhaler group.
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