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allopurinol facts description:

The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. Up to 300 milligrams (mg) of allopurinol can be taken at one time. This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. Unlike PURINETHOL (mercaptopurine) and IMURAN