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There are no data with Augmentin and allopurinol administered concurrently. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. Ask your health care provider if Allopurinol may interact with other medicines that you take. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans.

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