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1, the following adverse reactions have been identified during postapproval use of Ventolin HFA. Because of the potential for tumorigenicity shown for albuterol in animal studies and lack of experience with the use of Ventolin HFA by nursing mothers, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The data from adults and adolescents is based upon 2 clinical trials in which 202 patients with asthma 12 years of age and older were treated with Ventolin HFA 2 inhalations 4 times daily for 12 weeks’ duration. Fast-acting bronchodilators include albuterol (Ventolin, Proventil), bitolterol (Tornalate), metaproterenol (Alupent), and pirbuterol (Maxair). Table 1 lists the incidence of all adverse reactions (whether considered by the investigator to be related or unrelated to drug) from these studies that occurred at a rate of 3% or greater in the group treated with Ventolin HFA and more frequently in the group treated with Ventolin HFA than in the HFA-134a placebo inhaler group. Ventolin HFA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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