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Symptoms of a triamterene overdose may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms. Arrhythmias have been associated with HCTZ-induced hypokalemia; hypokalemia is much less likely with the addition of triamterene. A case of obstructive renal tubular triamterene calculi is reported. Triamterene renal calculi has been estimated to occur in 1/1,500 to 1/2,000 patients. A case of cholestatic jaundice and centrolobular necrosis of the liver has been associated with triamterene (probably related to hypersensitivity to the drug). Do not use potassium supplements or other diuretics while you are taking triamterene.
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